The "Cruel Absurdity” of Human Violence and Its Consequences A Vegan Studies Analysis of a Pandemic Novel

This article teases out what a Vegan Studies theoretical framework can offer a literary analysis of a selected pandemic novel, "The Fell” (2021), by Sarah Moss. Pandemic fiction accommodates texts from a wide range of genres, and these types of literary texts have seen a resurgence in the wake of the spread of the corona virus. While literary engagements with pandemics have often been relegated to the realms of dystopian science fiction, our current realities have shifted to such an extent that they can now comfortably be read alongside more realistic fictional representations of contemporary societies. The causal relationships between anthropocentric abuse of the environment in general and of animals in particular, and pandemics have been energetically contested in the media and in scholarly disciplinary fields ranging from Virology to Critical Animal Studies. The argument that I will develop is that Vegan Studies is a theoretical rubric with unique and salient generative capacity and that it allows for the emergence of fresh and necessary insights when we start unpacking how to make sense of pandemics through fiction. I will use Moss's novel to anchor and illustrate my argument in favour of the value of Vegan Studies in these discussions © 2022 Jessica Murray

Intelligent Surface-Enhanced Raman Scattering Sensor System for Virus Identification

COVID-19 has devastated the entire world for the past couple of years. Timely and efficient detection and identification of a virus are crucial in preventing the wider virus spread. By using intelligent sensors based on Surface-Enhanced Raman Scattering (SERS), it is possible to detect and identify virus automatically. In this study, we successfully applied the XGBoost Algorithm (Supervised Machine Learning) to classify the type of the virus using the SERS sensor data. The supervised approach has a limitation when a new type of virus arises, whose shape is different from the previously known samples. To tackle this problem, we investigated the unsupervised learning approaches that can cluster the virus data into different groups without labeled data. The unsupervised approach presented in this paper is called k-Shape Clustering. This technique compares the cross-correlation between different samples and then clusters them into similar or different groups. If a subvariant of a virus emerges, it would be clustered into the existing virus groups;if a new type of virus is found, it would be clustered into a new group. Both of the approaches have shown very promising results based on extensive evaluations. © 2022 IEEE.

Data analysis guidelines for single-cell RNA-seq in biomedical studies and clinical applications.

The application of single-cell RNA sequencing (scRNA-seq) in biomedical research has advanced our understanding of the pathogenesis of disease and provided valuable insights into new diagnostic and therapeutic strategies. With the expansion of capacity for high-throughput scRNA-seq, including clinical samples, the analysis of these huge volumes of data has become a daunting prospect for researchers entering this field. Here, we review the workflow for typical scRNA-seq data analysis, covering raw data processing and quality control, basic data analysis applicable for almost all scRNA-seq data sets, and advanced data analysis that should be tailored to specific scientific questions. While summarizing the current methods for each analysis step, we also provide an online repository of software and wrapped-up scripts to support the implementation. Recommendations and caveats are pointed out for some specific analysis tasks and approaches. We hope this resource will be helpful to researchers engaging with scRNA-seq, in particular for emerging clinical applications.

Real-time surveillance of severe acute respiratory infections in Scottish hospitals: an electronic register-based approach, 2017-2022.

OBJECTIVES: The COVID-19 pandemic highlighted the importance of routine syndromic surveillance of respiratory infections, specifically new cases of severe acute respiratory infection (SARI). This surveillance often relies on questionnaires carried out by research nurses or transcriptions of doctor's notes, but existing, routinely collected electronic healthcare data sets are increasingly being used for such surveillance. We investigated how patient diagnosis codes, recorded within such data sets, could be used to capture SARI trends in Scotland. STUDY DESIGN: We conducted a retrospective observational study using electronic healthcare data sets between 2017 and 2022. METHODS: Sensitive, specific and timely case definition (CDs) based on patient diagnosis codes contained within national registers in Scotland were proposed to identify SARI cases. Representativeness and sensitivity analyses were performed to assess how well SARI cases captured by each definition matched trends in historic influenza and SARS-CoV-2 data. RESULTS: All CDs accurately captured the peaks seen in laboratory-confirmed positive influenza and SARS-CoV-2 data, although the completeness of patient diagnosis records was discovered to vary widely. The timely CD provided the earliest detection of changes in SARI activity, whilst the sensitive CD provided insight into the burden and severity of SARI infections. CONCLUSIONS: A universal SARI surveillance system has been developed and demonstrated to accurately capture seasonal SARI trends. It can be used as an indicator of emerging secondary care burden of emerging SARI outbreaks. The system further strengthens Scotland's existing strategies for respiratory surveillance, and the methods described here can be applied within any country with suitable electronic patient records.

Promoting a health-centered approach to acute mental health crises on college campuses: The case for collegiate-based emergency medical services.

As college and university campuses re-open during the COVID-19 pandemic, there is increased concern for mental health crises. Current trends in campus mental health care emphasize providing quality care in a safe, non-judgmental, and non-punitive manner. Collegiate-based emergency medical services organizations are well-positioned to respond to acute mental health crises on college campuses. Campus health professionals and administrators seeking to promote a health-centered approach toward mental health crises should support the growth and development of collegiate-based emergency medical services organizations.

THE EFFECT OF HIDDEN CELIAC DISEASE ON COVID-19 IN THE COMMUNITY

Background: Celiac disease (CeD) is an autoimmune disorder characterized by an inflammatory immune response against gluten and increased susceptibility to bacterial and viral infections. After the coronavirus disease 2019 (COVID-19) pandemic began, several studies showed no difference in infections rates of SARS-CoV-2 between patients with CeD and the general population. However, all studies were based on diagnosed CeD patients who are likely on a gluten-free diet;the immune system of these patients is similar to the general population, which is not likely to show an increased risk of COVID-19. On the contrary, individuals with undiagnosed CeD are likely to be susceptible to viral infections due to abnormally overactivity of the immune system. We aimed to evaluate the frequency of SARSCoV- 2 positivity and related to hospitalization in hidden CeD patients and diagnosed CeD and compare the vaccination rate in these groups. Methods: Based on the previous community cohort of subjects who were tested for CeD serology, we categorized them into three groups: hidden CeD, diagnosed CeD, and seronegative controls. Data of COVID-19 were obtained from January 2020 through September 2021, utilizing polymerase chain reaction (PCR) test results for SARS-CoV-2 and corresponding hospitalization records. Results: A total of 207 hidden celiac disease, 68 diagnosed CeD, and 22,213 seronegative controls were included in the study. Table 1 summarizes the COVID-19 PCR tests, positivity rate, hospitalization, and vaccination rate. Remarkably, about two thirds of the community in the study population were tested for SARS-CoV-2. SARS-CoV-2 PCR tests were more frequently conducted in the diagnosed CeD group (78%), compared to the undiagnosed CeD (68%) or seronegative group (63%) (p=0.01). The positivity rate among subjects tested for SARSCoV- 2 was higher in the seronegative group (15.3%) than that of undiagnosed CeD (14.3%) or diagnosed CeD (7.5%), but it was not statistically significant. Of 2,125 subjects with positive SARS-CoV-2 results in the seronegative group, about 8.1% (n=172) were hospitalized, while only one patient with undiagnosed CeD (out of 20 positive cases) was hospitalized. Interestingly, vaccination rates among the three groups were similar (48% in the seronegative group, 49% in the undiagnosed CeD, and 53% in the diagnosed CeD). Conclusions: This study demonstrated no difference in susceptibility to SARS-CoV-2 infection in undiagnosed or diagnosed CeD. Testing rate is higher in diagnosed CeD, which is likely to be related to health-seeking behavior. (Table Presented)

Continuity, change and challenge: unearthing the (fr)agility of teacher education

In this final article, we bring together the issues raised by authors included in this special issue. We start by describing the current situation in our own countries, partly to highlight the different ways in which nations are responding in the longer term to the pandemic, but also to draw attention to the similarity of experience–of educators using digital technology, of concern with maintaining the supply of teachers, of the challenges relating to lockdowns–during its peak. We then reflect on the systemic issues that have been raised by the authors in this issue: what we call the (fr)agility of the teacher education system, in which educators’ adaptive response to the pandemic and subsequent desire for change can be met by institutional resistance;the multiple questions raised by the use of digital technologies;and the challenges relating to teacher and teacher educator adaptability and/or agility. In the final section, we reflect on what we (might) have learned from the pandemic and consider a future agenda for teacher educators. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Rapid and high-sensitive LSPR sensor for coronavirus detection

A rapid, portable, and cost-effective method to detect the infection of SARS-CoV-2 is fundamental toward mitigating the current COVID-19 pandemic. A localized surface plasmon resonance (LSPR) sensor based on human angiotensin-converting enzyme 2 protein (ACE2) functionalized silver nanotriangle array is developed for rapid coronavirus detection. The sensor is validated by SARS-CoV-2 spike RBD protein and CoV NL63 virus with high sensitivity and specificity. A linear shift of the LSPR wavelength and transmission intensity at a fixed wavelength (750 nm) versus the logarithm of the concentration of the spike RBD protein and CoV NL63 is observed. The limits of detection for the spike RBD protein, CoV NL63 in untreated saliva are determined to be 0.38 pM, and 625 PFU/mL, respectively, while the detection time is found to be less than 20 min. Such a LSPR sensor could serve as a potential rapid point-of-care diagnostic platform for COVID-19. © 2022 SPIE

Scheduling Diagnostic Testing Kit Deliveries with the Mothership and Drone Routing Problem.

A critical component in the public health response to pandemics is the ability to determine the spread of diseases via diagnostic testing kits. Currently, diagnostic testing kits, treatments, and vaccines for the COVID-19 pandemic have been developed and are being distributed to communities worldwide, but the spread of the disease persists. In conjunction, a strong level of social distancing has been established as one of the most basic and reliable ways to mitigate disease spread. If home testing kits are safely and quickly delivered to a patient, this has the potential to significantly reduce human contact and reduce disease spread before, during, and after diagnosis. This paper proposes a diagnostic testing kit delivery scheduling approach using the Mothership and Drone Routing Problem (MDRP) with one truck and multiple drones. Due to the complexity of solving the MDRP, the problem is decomposed into 1) truck scheduling to carry the drones and 2) drone scheduling for actual delivery. The truck schedule (TS) is optimized first to minimize the total travel distance to cover patients. Then, the drone flight schedule is optimized to minimize the total delivery time. These two steps are repeated until it reaches a solution minimizing the total delivery time for all patients. Heuristic algorithms are developed to further improve the computational time of the proposed model. Experiments are made to show the benefits of the proposed approach compared to the commonly performed face-to-face diagnosis via the drive-through testing sites. The proposed solution method significantly reduced the computation time for solving the optimization model (less than 50 minutes) compared to the exact solution method that took more than 10 hours to reach a 20% optimality gap. A modified basic reproduction rate (i.e., m R 0) is used to compare the performance of the drone-based testing kit delivery method to the face-to-face diagnostic method in reducing disease spread. The results show that our proposed method (m R 0= 0.002) outperformed the face-to-face diagnostic method (m R 0= 0.0153) by reducing m R 0 by 7.5 times.

Declining the COVID-19 vaccination: An evaluation of why some high risk cancer patients decline vaccination

The COVID-19 pandemic has created many challenges and barriers to care for patients on active cancer treatments including increased risk for morbidity and mortality from COVID-19 infection and restricted access to care. Specific patient groups, such as the uninsured and patients of underrepresented minority communities, have experienced this burden disproportionately. The rapid development and emergency authorization of COVID-19 vaccinations present an opportunity to mitigate some of this increased risk and improve health outcomes for patients on active cancer treatments. However, little is known regarding the rate of vaccination in this patient group. We study the rate of COVID-19 vaccination in a single institution infusion therapy clinic for cancer patients at a large academic county hospital in San Antonio which serves a high-risk patient population with a high representation of minority patient and uninsured patients. Patients were surveyed on arrival to the University Health System outpatient infusion clinic between May 2021 and June 2021. COVID-19 vaccinations became available to this patient population in February 2021. Starting the survey process three months after the first vaccination availability allowed sufficient time for patients to become fully vaccinated. Of the 194 patients surveyed between May 3, 2001 and June 25, 2021, 56% reported receiving at least one dose of a COVID-19 vaccination which is lower than the community vaccination rate of 76%. Patients were given 6 options to choose from for declining the vaccination. They included: 1. I do not think it is safe for me because I have cancer 2. My doctor has not told me to get the vaccine 3. I want the vaccine but have not been able to schedule an appointment 4. I'm afraid of the side effects 5. I already had COVID, so I do not think I need the vaccine 6. Other The most common reason given for declining the vaccination was "My doctor has not told me to get the vaccine" by 30% of patients and the second most common was "I do not think it is safe for me because I have cancer" by 28% of patients. "I'm afraid of the side effects" was thethird most common response given by 23% of patients. Interestingly, access to the vaccine was not a common reason with only 10% of patients reporting this reason for not getting vaccinated. The three most common reasons cancer patients declined the COVD-19 vaccination can all be addressed by improvement in patient/physician communication regarding the known safety of the novel COVID-19 vaccinations and the recommendation for cancer patients to be vaccinated to help improve overall safety of giving immunosuppressive medications during the pandemic. This study shows the impact that healthcare works can make in increasing the COVID-19 vaccination rate in a high-risk population.

Change from transrectal to transperineal ultrasound-guided prostate biopsy under local anaesthetic eliminates sepsis as a complication.

Transrectal ultrasound-guided (TRUS) biopsy of the prostate is associated with increased risk of post-procedural sepsis with associated morbidity, mortality, re-admission to hospital, and increased healthcare costs. In the study institution, active surveillance of post-procedural infection complications is performed by clinical nurse specialists for prostate cancer under the guidance of the infection prevention and control team. To protect hospital services for acute medical admissions related to the coronavirus disease 2019 (COVID-19) pandemic, TRUS biopsy services were reduced nationally, with exceptions only for those patients at high risk of prostate cancer. In the study institution, this change prompted a complete move to transperineal (TP) prostate biopsy performed in outpatients under local anaesthetic. TP biopsies eliminated the risk of post-procedural sepsis and, consequently, sepsis-related admission while maintaining a service for prostate cancer diagnosis during the COVID-19 pandemic.

Technical services and systems: Supporting student success during COVID-19

When faced with COVID-19 in March 2020, the University of North Florida (UNF) and Florida Gulf Coast University (FGCU) libraries quickly shifted gears to provide support for continuity of instruction and learning in a remote environment. Staff not only had to make the shift towards working remotely, but also had to find new and innovative ways to handle resources and services and make them as visible and accessible as possible. For-tunately, due to current technology and available tools, both libraries already had many resources and services available online, and it was easy to transition to those that were not. It wasn’t all easy though, and both libraries faced personnel and work challenges. Still, everyone worked together to do the best they could during a time of much uncertainty. © 2019 Association of College and Research Libraries, a division of the American Library Association.

Use of Cryopreserved Allogeneic PBSC Results in Delayed Engraftment and Increased Incidence of Poor Graft Function

Use of Cryopreserved Allogeneic PBSC Results in Delayed Engraftment And Increased Incidence of Poor Graft Function Introduction: During COVID Pandemic, national and international transplant centres agreed to use cryopreserve the donor PBSC as a safer option to deliver allogeneic transplants. Published data suggests that use of cryopreserved allogeneic PBSC is safe and comparable to use of fresh PBSC but cryopreservation of stem cells may lead to cell loss and hence efficacy. During COVID pandemic, use of cryopreserved allogeneic PBSC was adopted as policy on 01/06/2020. This look back analysis evaluates the impact of change in policy. Aims: Evaluate Engraftment time, compare with historical data, blood component support, and use of growth factors Methods and Materials: Data was collected from health records (paper and electronic) and laboratory records. Transplant features and engraftment kinetics were analysed. Results: Group A June 2020 to November 2020, 19 patients [M: 13;F: 6;median age: 50yr (range: 23-69)] who received cryopreserved allogeneic PBSC were compared to 35 patients [M:24;F:11;median age: 59yr (range: 21-71)] receiving fresh allogeneic PBSC for engraftment kinetics. There were no differences between two groups regarding underlying diagnosis (p=0.31), sex mismatch, CMV mismatch, blood group mismatch, reduced intensity conditioning [RIC](p=0.28), type of donor (p=0.98) or use of Alemtuzumab (p=0.88). Median infused Cell dose in group A was 5.3 (3.4-7.16) and in group B 4.9 (1.03-6.85), [p=0.11]. Neutrophil engraftment was significantly faster with fresh PBSC as compared to cryopreserved PBSC (16d vs. 25d, p=0.0025) predominantly with MUD (18d vs. 27d, p=0.009) and RIC (16d vs. 25d, p=0.009). Platelet engraftment to 25 was faster with fresh PBSC (13d vs. 20d, p=0.021) with delayed engraftment in MUD (20d vs. 13d, p=0.006) and RIC (23d vs. 13d, p=0.039). Day to engraftment per unit CD34 was shorter with fresh PBSC for neutrophils (median: 3.2, range: 2.0-7.7 vs. 5.3, range: 2.5-16.7;p=0.006) and platelets (median: 2.4, range: 1.7-25 vs. 3.8, range: 2.2-25;p=0.001) but only for MUD. This suggests 35-40% less efficiency with use of cryopreserved PBSC. There was no difference in the need for transfusion support [RBCs (6 units vs. 3 units, p=0.32);platelets (5 pools vs. 7 pools, p=0.33)]. G-CSF use was higher with cryopreserved PBSC in RIC (54% vs. 20%, p=0.031). Two patients experienced TRM before day 90 (3.7%). At day 90, 17/52 (32.7%) had cytopenia in one lineage and 8/52 (16%) had cytopenia in more than one lineage. Delayed engraftment was observed in 10 of 33 patients (30.3%) transplanted in 2020 and the only significant association was use of cryopreserved PBSC (0% vs. 53%, p=0.001). There was no difference in the incidence of aGVHD, hepatic VOD, microangiopathy and bacterial infections. Numbers are not sufficient to make disease specific comparisons. Conclusion: Cryopreserved PBSC result in delayed neutrophil and platelet engraftment predominantly with MUDS and RIC. Incidence of delayed engraftment and poor graft function is higher. Per unit CD34 dose, cryopreserved PBSC are 30-40% less efficient to achieve engraftment. Delayed engraftment with cryopreserved PBSC especially in MUD raises the possibility that time from harvest to cryopreservation contributes to reduced efficacy. Based on these findings it was decided to infuse higher CD34 dose (6-7x10

Shopping in a Pandemic: A Persuasive Game for COVID-19

Dino-Store is a persuasive game that was designed to use gamification way to communicate with people and raise awareness on COVID-19. The game's setting is grocery shopping and the mechanic indicates that how different protection strategies, such as wearing mask, keeping social distance can affect people's infection chances in the COVID-19 pandemic. This paper will break down how the game designed by merging concepts from persuasive game models and uncomfortable interaction theory to create an engaging, but stressful experience for the user. © 2021 Owner/Author.

National population prevalence of antibodies to SARS-CoV-2 in Scotland during the first and second waves of the COVID-19 pandemic.

OBJECTIVES: Studies that measure the prevalence of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ('seroprevalence') are essential to understand population exposure to SARS-CoV-2 among symptomatic and asymptomatic individuals. We aimed to measure seroprevalence in the Scottish population over the course of the COVID-19 pandemic - from before the first recorded case in Scotland through to the second pandemic wave. STUDY DESIGN: The study design of this study is serial cross sectional. METHODS: We tested 41,477 residual samples retrieved from primary and antenatal care settings across Scotland for SARS-CoV-2 antibodies over a 12-month period from December 2019-December 2020 (before rollout of COVID-19 vaccination). Five-weekly rolling seroprevalence estimates were adjusted for the sensitivity and specificity of the assays and weighted to reference populations. Temporal trends in seroprevalence estimates and weekly SARS-CoV-2 notifications were compared. RESULTS: Five-weekly rolling seroprevalence rates were 0% until the end of March, when they increased contemporaneously with the first pandemic wave. Seroprevalence rates remained stable through the summer (range: 3%-5%) during a period of social restrictions, after which they increased concurrently with the second wave, reaching 9.6% (95% confidence interval [CI]: 8.4%-10.8%) in the week beginning 28th December in 2020. Seroprevalence rates were lower in rural vs. urban areas (adjusted odds ratio [AOR]: 0.70, 95% CI: 0.61-0.79) and among individuals aged 20-39 years and 60 years and older (AOR: 0.74, 95% CI: 0.64-0.86; AOR: 0.80, 95% CI: 0.69-0.91, respectively) relative to those aged 0-19 years. CONCLUSIONS: After two waves of the COVID-19 pandemic, less than one in ten individuals in the Scottish population had antibodies to SARS-CoV-2. Seroprevalence may underestimate the true population exposure as a result of waning antibodies among individuals who were infected early in the first wave.

The Pickrick Protests: An Interactive Geo AR Experience

With AR's dynamic and immersive qualities, the Pickrick AR project aims to serve two purposes: to support the civil rights movement in remembrance of the African Americans who fought for equality and to educate students about this special moment in history via a pedagogical tool. With considerations of the Covid-19 pandemic, this tool aims to create an immersive and enlightening experience within the real physical space without the presence of a tour guide. In this paper, is an introduction to our design concepts, specifically in how to integrate multimedia information and create a user-friendly interface by using Human Computer Interaction (HCI) principles and the Sense of Place (SOP) Theory.

First-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland.

Reports of ChAdOx1 vaccine-associated thrombocytopenia and vascular adverse events have led to some countries restricting its use. Using a national prospective cohort, we estimated associations between exposure to first-dose ChAdOx1 or BNT162b2 vaccination and hematological and vascular adverse events using a nested incident-matched case-control study and a confirmatory self-controlled case series (SCCS) analysis. An association was found between ChAdOx1 vaccination and idiopathic thrombocytopenic purpura (ITP) (0-27 d after vaccination; adjusted rate ratio (aRR) = 5.77, 95% confidence interval (CI), 2.41-13.83), with an estimated incidence of 1.13 (0.62-1.63) cases per 100,000 doses. An SCCS analysis confirmed that this was unlikely due to bias (RR = 1.98 (1.29-3.02)). There was also an increased risk for arterial thromboembolic events (aRR = 1.22, 1.12-1.34) 0-27 d after vaccination, with an SCCS RR of 0.97 (0.93-1.02). For hemorrhagic events 0-27 d after vaccination, the aRR was 1.48 (1.12-1.96), with an SCCS RR of 0.95 (0.82-1.11). A first dose of ChAdOx1 was found to be associated with small increased risks of ITP, with suggestive evidence of an increased risk of arterial thromboembolic and hemorrhagic events. The attenuation of effect found in the SCCS analysis means that there is the potential for overestimation of the reported results, which might indicate the presence of some residual confounding or confounding by indication. Public health authorities should inform their jurisdictions of these relatively small increased risks associated with ChAdOx1. No positive associations were seen between BNT162b2 and thrombocytopenic, thromboembolic and hemorrhagic events.

The Considerations and Controversies in Using High-Flow Nasal Oxygen with Self-Prone Positioning in SARS-CoV-2 COVID-19 Disease.

Evidence exists for the use of high-flow nasal oxygen (HFNO) in the general critical care population for acute hypoxemic respiratory failure. There is discord between guidelines for hypoxemia management in COVID-19. Both noninvasive management and intubation present risk to patients and staff and potentially overwhelm hospital mechanical ventilator capacity. The use of HFNO has been particularly controversial in the UK, with oxygen infrastructure failure. We discuss our experience of managing COVID-19 with HFNO and awake self-prone positioning. We focus upon the less-usual case of an eighteen-year-old female to illustrate the type of patient where HFNO may be used when perhaps earlier intubation once was. It is important to consider the wider implications of intubation. We have used HFNO as a bridge to intubation or as definitive management. As we await clinical trial evidence, HFNO with self-prone positioning has a role in COVID-19 for certain patients. Response parameters must be set and reviewed, oxygen infrastructure considered, and potential staff droplet exposure minimised.

The impact of a dedicated pediatric stroke discharge plan upon parent preparedness for clinic: Before and after the start of COVID-19

Background: The Colorado Pediatric Stroke Program provides comprehensive, multidisciplinary care for pediatric stroke patients and their families. The team, which includes dedicated inpatient and outpatient nurse coordinators, instituted a plan to support the transition from the inpatient to outpatient setting. Purpose: A survey was used to determine family preparedness for clinic and ease of scheduling their appointment. The data were collected before and after enacting remote scheduling and telehealth visits due to the COVID-19 pandemic. Methods: Our team provided educational materials and an outpatient appointment time to families at time of discharge starting in 2019. In January 2020, the stroke clinic staff surveyed parents and guardians about their preparedness for clinic. Telehealth encounters were initiated due to COVID-19 in March 2020, with staff conducting RedCAP surveys by telephone. The survey measured several components of visit preparedness and satisfaction including: understanding of diagnosis, reason for referral prior to clinic visit, familiarity with the stroke team prior to clinic visit, and ease in appointment scheduling. We compared results before and after March 2020 via two-tailed chisquare analysis or two-tailed Fischer's test. Results: Prior to telehealth, families favorably reported responses with 92% (47/52) knowing the reason for referral, 86% (42/49) receiving educational material prior to clinic, and 84% (42/50) reporting familiarity with our team. All patients (50/50) reported that scheduling was easy. Only scheduling ease had a significant change during the pandemic, with 11% (2/11) of patients reporting difficulties with scheduling after starting telehealth (P=0.03). Conclusion: Childhood stroke is a disease with significant morbidity and mortality, requiring close follow-up care. Families report robust preparedness for clinic after the implementation of a comprehensive discharge plan. Although small numbers, remote scheduling and telehealth transition may present previously unseen barriers to scheduling during the pandemic. During abrupt changes in clinical operations additional scheduling resources may be needed to ensure continuity of care.